Experimenting with vector Paint Synth Presets in Studio Artist.
Some key aspects of a hand painted effect like this are the texture and interesting impression of a wet mix (tho the stroke is laid on opaque)
An organic and textured look that can't be reproduced with standard digital art tools.
(cd_vect sample shape brush 5 sm1 and sm2 - fills
cd_vect_et_bleed3 for the lines)